"The participants reported overall favorable results and improvements in all individual categories, were satisfied with the treatment, and would recommend the product to others. The participants perceived the greatest improvement in fine lines and wrinkles, skin texture, and youthful appearance. Photographic digital analysis demonstrated favorable improvements in wrinkles, UV spots, brown spots, pores, and porphyrins."

"After in vitro and ex vivo investigations, a clinical study assessed the safety and efficacy of a daily treatment with the home-use device for 28 days. A significant increases in skin density and radiance while reducing the wrinkles was obtained with no side effects."

"All 24 subjects completed the study and attended all follow-up. Skin elasticity was significantly higher in the LED group compared to the control during the 6- and 8-week follow-up (p < 0.05). In the LED group, an image of the treated skin captured using Visioscan® showed improvement of the skin texture at 8-week follow-up. Majority of the subjects in the LED group scored good improvement on all follow-ups (37.5%, 41.7%, 58.3% and 62.5%) when compared to the baseline. No adverse reactions or pain were recorded in the study." Comment: Only 2 of the 10 statistical intergroup tests showed significant difference. without correction for multiple testing (eg. Bonferroni)

"The application of LLLT, EA, and RF had positive effects on wrinkle and moisture content of adult women's faces."

"In their study, Buscone et al.44 (2021) now report that the exposure of human scalp HFs to blue light (453 nm) leads to an intrafollicular accumulation of CRY1 protein. This CRY1 stimulation prolongs anagen, while CRY1 silencing promotes catagen development ex vivo. The authors also find CRY1 protein to be prominently expressed in human scalp HFs during anagen, notably including in epithelial stem/progenitor cells.44 This is in line with the concept that the previously reported hair growth stimulation by blue light48 is mediated, at least in part, by CRY1—inviting the direct targeting of CRY1 expression/activity in the future management of both, hair loss (alopecia, effluvium) and unwanted hair growth (hirsutism, hypertrichosis)."

"Here, we show that 453 nm blue light induces cryptochrome 1 (CRY1) accumulation in human keratinocytes and the hair follicle. CRY1 is prominently expressed in the human anagen hair follicle, including epithelial stem cells. Specific silencing of CRY1 promotes catagen, while stimulation of CRY1 by KL001 prolongs anagen ex vivo by altering the expression of genes involved in apoptosis and proliferation."

"Our research shows that individuals with Fitzpatrick phototypes II to III can treat facial melasma with the 675-nm laser source system without risk. Due to its interaction with melanin, collagen and haemoglobin chromophores, as well as its excellent capacity to penetrate tissues with less heating, this system is promising in the treatment of pigmentary and vascular illnesses such as melasma. The great success of the technology we used came from the reduced levels of inflammation produced after the treatments and the low energy level implied."

"Both subjective and objective results indicated a significant improvement of melasma. Statistical analyses revealed significant improvements in both groups."

"Significant improvements in acne lesions (assessed as non-inflammatory and inflammatory lesion counts) and a significant decrease in skin sebum excretion were observed after the treatment. No adverse effects were reported."

"As it is confirmed by our findings, the combination of blue and red light is more effective in treatment of acne vulgaris rather than blue light alone, with no significant adverse effects."

"Evaluation using the Lemperle wrinkle scale and global improvement scales by both investigators and subjects showed significant improvement after 16 weeks of daily application, as well as 8 weeks after discontinuation. Biophysical parameters, such as hydration, elasticity, and density, also showed significant improvements."

"Fifteen studies were found to be strongly relevant and were analyzed. Studies have shown that LLLT stimulated hair growth in both men and women. Studies with largest randomized controlled trials demonstrated statistically significant hair regrowth by terminal hair count in both males and females. One study also showed that LLLT and minoxidil had similar efficacy in hair growth and that combination therapy was even more effective."

"Reduction of erythema was considered significant when erythema was reduced by >50% on the LED-treated side as opposed to CONTROL side. A significant LED treatment reduction in UV-B induced erythema reaction was observed in at least one occasion in 85% of subjects, including patients suffering from PLE. Moreover, there was evidence of a dose-related pattern in results. Finally, a sun protection factor SPF-15-like effect and a reduction in post-inflammatory hyperpigmentation were observed on the LED pre-treated side."

"The intriguing topic that will be addressed as follows is that photobiomodulation therapy (PBMT) may be able to treat various types of pigmentation disorders and exert seemingly opposite effects depending on the result required."

"The median time to healing for the active group was 129 h, compared with 177 h for the control group, which was significant (P = 0.01)."